http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=pubmed&term=%28fatty%20acid%20and%20synapse%29%20or%20%28fatty%20acids%20and%20synapse%29 Fatty acids and synapse collection by Neurobiology of Lipids (ISSN 1683-5506) - alerts interested readers about latest peer reviewed scholar publications on neuroscience of fatty acids en-us http://blogs.law.harvard.edu/tech/rss 1440 http://neurobiologyoflipids.org/http://neurobiologyoflipids.org/images/neurobiologyoflipidslogo250x50.jpg 1642887http://www.feedburner.comSubscribe with My Yahoo!Subscribe with NewsGatorSubscribe with My AOLSubscribe with RojoSubscribe with BloglinesSubscribe with NetvibesSubscribe with GoogleSubscribe with PageflakesSubscribe with PlusmoSubscribe with FeedLoungeSubscribe with The Free DictionarySubscribe with Bitty BrowserSubscribe with Live.comSubscribe with Excite MIXSubscribe with Yourminis.comSubscribe with Attensa for OutlookSubscribe with WebwagSubscribe with netomat HubSubscribe with Daily RotationSubscribe with Podcast ReadySubscribe with FlurrySubscribe with ParticlsAdd to Any Feed ReaderSubscribe with fwickiSubscribe with Zune MarketplaceThis is Neurobiology of Lipids specialist content summary only. Click on the Journal logo above to visit NoL home page for original content, other collections, and more http://rss.neurobiologyoflipids.org/~r/fattyacidsynapse/~3/342724139/query.fcgi <table border="0" width="100%"><tr><td align="left"/><td align="right"><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Display&amp;dopt=PubMed_PubMed&amp;from_uid=18631994">Related Articles</a></td></tr></table> <p><b>Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses.</b></p> <p>Alzheimers Dement. 2008 Jan;4(1 Suppl 1):S153-68</p> <p>Authors: Cansev M, Wurtman RJ, Sakamoto T, Ulus IH</p> <p>Although cognitive performance in humans and experimental animals can be improved by administering omega-3 fatty acid docosahexaenoic acid (DHA), the neurochemical mechanisms underlying this effect remain uncertain. In general, nutrients or drugs that modify brain function or behavior do so by affecting synaptic transmission, usually by changing the quantities of particular neurotransmitters present within synaptic clefts or by acting directly on neurotransmitter receptors or signal-transduction molecules. We find that DHA also affects synaptic transmission in mammalian brain. Brain cells of gerbils or rats receiving this fatty acid manifest increased levels of phosphatides and of specific presynaptic or postsynaptic proteins. They also exhibit increased numbers of dendritic spines on postsynaptic neurons. These actions are markedly enhanced in animals that have also received the other two circulating precursors for phosphatidylcholine, uridine (which gives rise to brain uridine diphosphate and cytidine triphosphate) and choline (which gives rise to phosphocholine). The actions of DHA aere reproduced by eicosapentaenoic acid, another omega-3 compound, but not by omega-6 fatty acid arachidonic acid. Administration of circulating phosphatide precursors can also increase neurotransmitter release (acetylcholine, dopamine) and affect animal behavior. Conceivably, this treatment might have use in patients with the synaptic loss that characterizes Alzheimer's disease or other neurodegenerative diseases or occurs after stroke or brain injury.</p> <p>PMID: 18631994 [PubMed - in process]</p><img src="http://rss.neurobiologyoflipids.org/~r/fattyacidsynapse/~4/342724139" height="1" width="1"/> Cansev M, Wurtman RJ, Sakamoto T, Ulus IH Alzheimers Dement PubMed:18631994 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=18631994&dopt=Abstract