http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Search&db=pubmed&term=%28lipoproteins%20and%20synapse%29%20or%20%28lipoprotein%20and%20synapse%29 Lipoproteins and synapse collection by Neurobiology of Lipids (ISSN 1683-5506) - alerts interested readers about latest peer reviewed scholar publications on neuroscience of lipoproteins en-us http://blogs.law.harvard.edu/tech/rss 1440 http://neurobiologyoflipids.org/http://neurobiologyoflipids.org/images/neurobiologyoflipidslogo250x50.jpg 1642794http://www.feedburner.comSubscribe with My Yahoo!Subscribe with NewsGatorSubscribe with My AOLSubscribe with RojoSubscribe with BloglinesSubscribe with NetvibesSubscribe with GoogleSubscribe with PageflakesSubscribe with PlusmoSubscribe with FeedLoungeSubscribe with The Free DictionarySubscribe with Bitty BrowserSubscribe with Live.comSubscribe with Excite MIXSubscribe with Yourminis.comSubscribe with Attensa for OutlookSubscribe with WebwagSubscribe with netomat HubSubscribe with Daily RotationSubscribe with Podcast ReadySubscribe with FlurrySubscribe with ParticlsAdd to Any Feed ReaderThis is Neurobiology of Lipids specialist content summary only. Click on the Journal logo above to visit NoL home page for original content, other collections, and more http://rss.neurobiologyoflipids.org/~r/lipoproteinsynapse/~3/322198177/query.fcgi <table border="0" width="100%"><tr><td align="left"><a href="http://www.pnas.org/cgi/pmidlookup?view=long&amp;pmid=18523004"><img src="http://www.ncbi.nlm.nih.gov/entrez/query/egifs/http:--highwire.stanford.edu-icons-externalservices-pubmed-custom-pnas_full.gif" border="0"/></a> <a href="http://hwmaint.pnas.org/cgi/pmidlookup?view=long&amp;pmid=18523004"><img src="http://www.ncbi.nlm.nih.gov/entrez/query/egifs/http:--highwire.stanford.edu-icons-externalservices-pubmed-custom-pnas_full_free.gif" border="0"/></a> <a href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&amp;pubmedid=18523004"><img src="http://www.ncbi.nlm.nih.gov/entrez/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif" border="0"/></a> </td><td align="right"><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&amp;cmd=Display&amp;dopt=PubMed_PubMed&amp;from_uid=18523004">Related Articles</a></td></tr></table> <p><b>Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus.</b></p> <p>Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8142-7</p> <p>Authors: Edwards DA, Zhang L, Alger BE</p> <p>The modifiability of neuronal response plasticity is called "metaplasticity." In suppressing synaptic inhibition and facilitating induction of long-term excitatory synaptic plasticity, endocannabinoids (eCBs) act as agents of metaplasticity. We now report the discovery of a calcium-dependent mechanism that regulates eCB mobilization by metabotropic glutamate receptor (mGluR) activation. The switch-like mechanism primes cells to release eCBs and requires a transient rise in intracellular Ca2+ concentration ([Ca2+]i) but not concurrent activation of mGluRs. Conversely, short-term, [Ca2+]i-dependent eCB release can be persistently enhanced by mGluR activation. Hence, eCBs are also objects of metaplasticity, subject to higher levels of physiological control.</p> <p>PMID: 18523004 [PubMed - indexed for MEDLINE]</p><img src="http://rss.neurobiologyoflipids.org/~r/lipoproteinsynapse/~4/322198177" height="1" width="1"/> Edwards DA, Zhang L, Alger BE Proc Natl Acad Sci U S A PubMed:18523004 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=18523004&dopt=Abstract